肾素-血管紧张素系统的核心组成部分。
Central components of the renin-angiotensin system.
作者信息
Hayden J, Targett M A
出版信息
Br J Pharmacol. 1971 Feb;41(2):177-86. doi: 10.1111/j.1476-5381.1971.tb08020.x.
Abstract
- Re-establishment of renal blood flow after total renal ischaemia of 4 h duration causes a pressor response in pentobarbitone anaesthetized rats and cats.2. The pressor response is related to the release of renin from the ischaemic kidney.3. Spinal section at any cervical level or stellate ganglionectomy abolishes the pressor response but spinal section caudad to the thorax or vagotomy and treatment with hexamethonium have no effect.4. Spinal section and stellate ganglionectomy interfere with the release of renin and with the pressor response to angiotensin.
摘要
持续4小时的全肾缺血后肾血流的重新建立会在戊巴比妥麻醉的大鼠和猫中引起升压反应。
升压反应与缺血肾脏中肾素的释放有关。
在任何颈椎水平进行脊髓横断或星状神经节切除术可消除升压反应，但在胸部以下进行脊髓横断、迷走神经切断术以及用六甲铵治疗均无效果。
脊髓横断和星状神经节切除术会干扰肾素的释放以及对血管紧张素的升压反应。
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引用本文的文献
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Renin release from the ischaemic kidney.缺血性肾释放肾素。
Br J Pharmacol. 1973 May;48(1):97-105. doi: 10.1111/j.1476-5381.1973.tb08226.x.
2
The mechanism of renin release from the ischaemic kidney.缺血性肾脏释放肾素的机制。
Br J Pharmacol. 1974 Apr;50(4):601-2. doi: 10.1111/j.1476-5381.1974.tb08595.x.
3
Inhibition by spinal transection of renin release from ischaemic rat kidneys.脊髓横断对缺血大鼠肾脏肾素释放的抑制作用。
Br J Pharmacol. 1971 Aug;42(4):649P-650P.
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