昆虫匀浆中微粒体氧化的抑制剂。
Inhibitors of microsomal oxidations in insect homogenates.
作者信息
Chakroborty J, Sissons C H, Smith J N
出版信息
Biochem J. 1967 Feb;102(2):492-7. doi: 10.1042/bj1020492.
Abstract
- Homogenates of insect tissues were assayed for enzymes capable of oxidizing p-nitrotoluene to p-nitrobenzoic acid. 2. Locust fat-body homogenate 10000g supernatant was an effective enzyme and required no added cofactors. 3. Homogenates of other insects or locust organs and 10000g sediment from locust fat-body were not active and inhibited microsomal oxidations carried out by locust fat-body or rabbit liver enzyme. 4. Inhibitory power was high in homogenates of whole flies and of fly heads or thoraces. 5. Inhibition appeared to involve both irreversible inactivation of enzyme and the removal of essential cofactors.
摘要
- 对昆虫组织匀浆进行检测，以寻找能够将对硝基甲苯氧化为对硝基苯甲酸的酶。2. 蝗虫脂肪体匀浆10000g上清液是一种有效的酶，且无需添加辅助因子。3. 其他昆虫或蝗虫器官的匀浆以及蝗虫脂肪体10000g沉淀物均无活性，且会抑制蝗虫脂肪体或兔肝酶进行的微粒体氧化。4. 全蝇以及蝇头或蝇胸的匀浆具有较高的抑制能力。5. 抑制作用似乎既涉及酶的不可逆失活，也涉及必需辅助因子的去除。
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