环己酰亚胺未能在麻醉大鼠中诱导酪氨酸转氨酶。
Failure of cycloheximide to induce tyrosine transaminase in the anesthetized rat.
作者信息
Mavrides C, Lane E A
出版信息
Science. 1967 Jun 9;156(3780):1376-8. doi: 10.1126/science.156.3780.1376.
PMID:4388260
Abstract
It was recently reported that cycloheximide, an inhibitor of protein synthesis, induces tyrosine transaminase in the liver of adrenalectomized rats. We have been unable to confirm this effect in the anesthetized animal and our data show that cycloheximide inhibits the induction caused by hydrocortisone in adrenalectomized rats or by stress in intact rats.
摘要
最近有报道称，蛋白质合成抑制剂环己酰亚胺可诱导肾上腺切除大鼠肝脏中的酪氨酸转氨酶。我们无法在麻醉动物中证实这种效应，且我们的数据表明，环己酰亚胺可抑制肾上腺切除大鼠中氢化可的松或完整大鼠中应激所引起的诱导作用。
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