Mosier D E, Johnson B M, Paul W E, McMaster P R
J Exp Med. 1974 May 1;139(5):1354-60. doi: 10.1084/jem.139.5.1354.
The cellular requirements for the primary in vitro IgM and IgG response to dinitrophenyl-substituted Ficoll were examined. Neither thymus-derived lymphocytes nor macrophage-rich splenic adherent cells were required for anti-DNP antibody synthesis. DNP-Ficoll is therefore tentatively classified as a "thymic-independent" antigen.
研究了对二硝基苯基取代的聚蔗糖进行体外初次 IgM 和 IgG 反应的细胞需求。抗二硝基苯酚(DNP)抗体合成既不需要胸腺来源的淋巴细胞,也不需要富含巨噬细胞的脾脏黏附细胞。因此,DNP-聚蔗糖被暂时归类为“非胸腺依赖性”抗原。