对二硝基苯基-聚蔗糖进行初次体外抗体应答的细胞需求
Cellular requirements for the primary in vitro antibody response to DNP-ficoll.
作者信息
Mosier D E, Johnson B M, Paul W E, McMaster P R
出版信息
J Exp Med. 1974 May 1;139(5):1354-60. doi: 10.1084/jem.139.5.1354.
Abstract
The cellular requirements for the primary in vitro IgM and IgG response to dinitrophenyl-substituted Ficoll were examined. Neither thymus-derived lymphocytes nor macrophage-rich splenic adherent cells were required for anti-DNP antibody synthesis. DNP-Ficoll is therefore tentatively classified as a "thymic-independent" antigen.
摘要
研究了对二硝基苯基取代的聚蔗糖进行体外初次 IgM 和 IgG 反应的细胞需求。抗二硝基苯酚（DNP）抗体合成既不需要胸腺来源的淋巴细胞，也不需要富含巨噬细胞的脾脏黏附细胞。因此，DNP-聚蔗糖被暂时归类为“非胸腺依赖性”抗原。
相似文献
1
Cellular requirements for the primary in vitro antibody response to DNP-ficoll.对二硝基苯基-聚蔗糖进行初次体外抗体应答的细胞需求
J Exp Med. 1974 May 1;139(5):1354-60. doi: 10.1084/jem.139.5.1354.
2
3
Aberrant maturation of the immune response to the thymus-independent antigen DNP-Lys--Ficoll by New Zealand Black mice.新西兰黑鼠对胸腺非依赖性抗原二硝基苯基-赖氨酸-聚蔗糖的免疫反应异常成熟。
Clin Immunol Immunopathol. 1980 Mar;15(3):472-80. doi: 10.1016/0090-1229(80)90059-8.
4
5
The immunological properties of haptens coupled to thymus-independent carrier molecules. IV. The IgG response to dinitrophenylated Ficoll.与非胸腺依赖性载体分子偶联的半抗原的免疫学特性。IV. 对二硝基苯基化聚蔗糖的IgG反应
Eur J Immunol. 1976 Jun;6(6):429-33. doi: 10.1002/eji.1830060610.
6
Regulation of immunoglobulin synthesis by dextran.右旋糖酐对免疫球蛋白合成的调节
J Exp Med. 1973 Jul 1;138(1):176-93. doi: 10.1084/jem.138.1.176.
7
A comparative study on the humoral immune responses in germ-free and conventional mice.无菌小鼠和普通小鼠体液免疫反应的比较研究。
Immunology. 1977 Jan;32(1):43-8.
8
Selective roles of thymus-derived lymphocytes in the antibody response. I. Differential suppressive effect of carrier-primed T cells on hapten-specific IgM and IgG antibody responses.胸腺来源淋巴细胞在抗体应答中的选择性作用。I. 载体致敏T细胞对半抗原特异性IgM和IgG抗体应答的差异抑制作用。
J Exp Med. 1974 Jul 1;140(1):239-52. doi: 10.1084/jem.140.1.239.
9
Thymus dependence of the IgA response to sheep erythrocytes.IgA对绵羊红细胞反应的胸腺依赖性
Immunology. 1975 Feb;28(2):287-91.
10
Anti-DNP antibody responses to DNP-histone H1 in mice.小鼠对二硝基苯基组蛋白H1的抗二硝基苯基抗体反应。
Immunology. 1979 Nov;38(3):569-75.
引用本文的文献
1
2
B-lymphocyte responses to trinitrophenyl-conjugated Ficoll: requirement for T lymphocytes and Ia-bearing adherent cells.B淋巴细胞对三硝基苯基偶联的聚蔗糖的反应：对T淋巴细胞和Ia抗原阳性黏附细胞的需求
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5113-7. doi: 10.1073/pnas.78.8.5113.
3
Dissociation of the anti-hapten and anti-carrier responses of mice injected with dinitrophenylated lipopolysaccharide.注射二硝基苯基化脂多糖的小鼠抗半抗原和抗载体反应的解离
Infect Immun. 1981 Jan;31(1):327-33. doi: 10.1128/iai.31.1.327-333.1981.
4
Specific cellular stimulation in the primary immune response: experimental test of a quantized model.初次免疫应答中的特异性细胞刺激：量化模型的实验测试
Proc Natl Acad Sci U S A. 1982 Feb;79(3):884-8. doi: 10.1073/pnas.79.3.884.
5
Selective immunosuppression resulting from exposure to the carcinogenic congener of benzopyrene in B6C3F1 mice.B6C3F1小鼠接触苯并芘致癌同系物后产生的选择性免疫抑制。
Clin Exp Immunol. 1983 Apr;52(1):199-206.
6
IR gene regulation of the response to trinitrophenyl-polysaccharides. Two independent genes are required for antibody production.对三硝基苯基多糖反应的免疫反应基因调控。抗体产生需要两个独立的基因。
J Exp Med. 1983 Jun 1;157(6):2002-16. doi: 10.1084/jem.157.6.2002.
7
Monoclonal antibody characterization of a unique immune response control locus between H-2S and D.H-2S与D之间独特免疫反应控制位点的单克隆抗体特性分析
J Exp Med. 1985 Nov 1;162(5):1477-93. doi: 10.1084/jem.162.5.1477.
8
9
Optimal strategies in immunology. I. B-cell differentiation and proliferation.免疫学中的最佳策略。I. B细胞分化与增殖。
J Math Biol. 1976 Nov 25;3(3-4):325-67. doi: 10.1007/BF00275065.
10
Murine B-cell subpopulations responsive to T-dependent and T-independent antigens.对T细胞依赖性和T细胞非依赖性抗原产生反应的小鼠B细胞亚群。
J Exp Med. 1976 Aug 1;144(2):382-97. doi: 10.1084/jem.144.2.382.
本文引用的文献
1
A requirement for two cell types for antibody formation in vitro.体外抗体形成需要两种细胞类型。
Science. 1967 Dec 22;158(3808):1573-5. doi: 10.1126/science.158.3808.1573.
2
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
3
Cell interactions in the primary immune response in vitro: a requirement for specific cell clusters.体外初次免疫应答中的细胞相互作用：特定细胞簇的需求。
J Exp Med. 1969 Feb 1;129(2):351-62. doi: 10.1084/jem.129.2.351.
4
The role of nonlymphoid accessory cells in the immune response to different antigens.非淋巴细胞辅助细胞在针对不同抗原的免疫反应中的作用。
J Exp Med. 1970 Mar 1;131(3):461-82. doi: 10.1084/jem.131.3.461.
5
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
6
Induction of immunity and tolerance in vitro by hapten protein conjugates. I. The relationship between the degree of hapten conjugation and the immunogenicity of dinitrophenylated polymerized flagellin.半抗原蛋白偶联物在体外诱导免疫和耐受。I. 二硝基苯基化聚合鞭毛蛋白的半抗原偶联程度与免疫原性之间的关系。
J Exp Med. 1972 Apr 1;135(4):735-53. doi: 10.1084/jem.135.4.735.
7
Frequency of antigen-sensitive cells to thymus-independent antigens.抗原敏感细胞对非胸腺依赖性抗原的反应频率。
Cell Immunol. 1971 Aug;2(4):309-16. doi: 10.1016/0008-8749(71)90065-7.
8
Evidence for thymus-independent humoral antibody production in mice against polyvinylpyrrolidone and E. coli lipopolysaccharide.小鼠体内针对聚乙烯吡咯烷酮和大肠杆菌脂多糖的非胸腺依赖性体液抗体产生的证据。
Cell Immunol. 1971 Oct;2(5):411-24. doi: 10.1016/0008-8749(71)90052-9.
9
Immune responses in vitro. 3. Development of primary gamma-M, gamma-G, and gamma-A plaque-forming cell responses in mouse spleen cell cultures stimulated with heterologous erythrocytes.体外免疫反应。3. 用异种红细胞刺激小鼠脾细胞培养物中主要γ-M、γ-G和γ-A斑块形成细胞反应的发展。
J Exp Med. 1971 Aug 1;134(2):395-416. doi: 10.1084/jem.134.2.395.
10
Induction of B cell tolerance in vitro to 2,4-dinitrophenyl coupled to a copolymer of D-glutamic acid and D-lysine (DNP-D-GL).体外诱导B细胞对与D-谷氨酸和D-赖氨酸共聚物偶联的2,4-二硝基苯基（DNP-D-GL）产生耐受性。
J Exp Med. 1973 Jul 1;138(1):312-7. doi: 10.1084/jem.138.1.312.
Zotero 插件