输注胆盐对大鼠的利胆和胆汁淤积作用。
Choleretic and cholestatic effects of infused bile salts in the rat.
作者信息
Drew R, Priestly B G
出版信息
Experientia. 1979 Jun 15;35(6):809-11. doi: 10.1007/BF01968265.
PMID:467601
Abstract
In rats, at low infusion rates taurocholate (TC), taurochenodeoxycholate (TCDC) and taurodeoxycholate (TCD) each produced an increase in bile flow of 20-50%. However, at high infusion rates (5-20 mumoles min-1kg-1) the cholestatic effects of the bile salts were revealed and the relative toxicity of the bile salts was seen to be TDC greater than TCDC greater than TC.
摘要
在大鼠中，低输注速率下，牛磺胆酸盐（TC）、牛磺鹅去氧胆酸盐（TCDC）和牛磺去氧胆酸盐（TCD）各自使胆汁流量增加20%-50%。然而，在高输注速率（5-20微摩尔·分钟⁻¹·千克⁻¹）时，胆盐的胆汁淤积作用显现出来，并且胆盐的相对毒性表现为TCD大于TCDC大于TC。
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