Monaco F, Fumero S, Mondino A, Mutani R
J Neurol Neurosurg Psychiatry. 1979 Jul;42(7):640-1. doi: 10.1136/jnnp.42.7.640.
Tryptophan and competing neutral amino acid levels were found to be diminished in the plasma of patients with multiple sclerosis and degenerative diseases, the greatest decrease being of tryptophan. Cerebrospinal fluid tryptophan was decreased in multiple sclerosis and motor neurone disease, while leucine and valine were increased. These changes might lead to decreased synthesis of brain serotonin and brain proteins. The ratio between neutral amino acids and tryptophan might be used as an ancillary test in the screening of degenerative diseases.
多发性硬化症和退行性疾病患者的血浆中色氨酸和竞争性中性氨基酸水平降低,其中色氨酸下降幅度最大。多发性硬化症和运动神经元疾病患者的脑脊液中色氨酸减少,而亮氨酸和缬氨酸增加。这些变化可能导致脑血清素和脑蛋白合成减少。中性氨基酸与色氨酸的比例可用作退行性疾病筛查的辅助检测指标。