1-甲基-3-硝基-1-亚硝基胍的抗菌评估
Antimicrobial evaluation of 1-methyl-3-nitro-1-Nitrosoguanidine.
作者信息
Hunt D E, Pittillo R F
出版信息
Appl Microbiol. 1968 Dec;16(12):1879-80. doi: 10.1128/am.16.12.1879-1880.1968.
Abstract
1-Methyl-3-nitro-1-nitrosoguanidine was shown to have in vitro antimicrobial activity against fungi and gram-positive and gram-negative bacteria; it was also shown to have in vivo activity in mice experimentally infected with Staphylococcus aureus or Escherichia coli comparable to that observed with penicillin or streptomycin sulfate.
摘要
1-甲基-3-硝基-1-亚硝基胍已被证明在体外对真菌、革兰氏阳性菌和革兰氏阴性菌具有抗菌活性；在实验感染金黄色葡萄球菌或大肠杆菌的小鼠体内也显示出与青霉素或硫酸链霉素相当的活性。
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本文引用的文献
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Filament formation and resistane to 1-methyl-3-nitro-1-nitrosoguanidine and other radiomimetic compounds in Escherichia coli.大肠杆菌中丝状形成以及对1-甲基-3-硝基-1-亚硝基胍和其他拟辐射化合物的抗性
J Bacteriol. 1961 Feb;81(2):258-66. doi: 10.1128/jb.81.2.258-266.1961.
3
Antifungal action of 1,3-bis(2-chloroethyl)-1-nitrosourea.1,3-双(2-氯乙基)-1-亚硝基脲的抗真菌作用
Antimicrob Agents Chemother (Bethesda). 1965;5:710-6.
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The physiological disposition of the carcinostatic 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in man and animals.抗癌药1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀）在人和动物体内的生理分布。
Clin Pharmacol Ther. 1967 Jul-Aug;8(4):566-77. doi: 10.1002/cpt196784566.
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