新生儿高胆红素血症及苯巴比妥治疗中的血糖变化

Blood sugar changes in neonatal hyperbilirubinaemia and phenobarbitone therapy.

作者信息

Yeung C Y

出版信息

Arch Dis Child. 1972 Apr;47(252):246-9. doi: 10.1136/adc.47.252.246.

DOI:10.1136/adc.47.252.246

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1648039/

Abstract

A controlled study was carried out to show the effect of bilirubinaemia and phenobarbitone therapy on the blood sugar metabolism in newborn infants. In the control infants, a significant inverse correlation existed between the serum bilirubin and the blood sugar levels in the first 4 days. The liver seemed to be a factor in producing such a relation. Glucose may be a useful adjunct to the treatment of neonatal hyperbilirubinaemia. Phenobarbitone therapy had significantly raised the blood sugar levels and lowered the serum bilirubin levels in these infants. It is suggested that enhancement of liver function or induction of hepatic enzymes may be the cause.

摘要

开展了一项对照研究，以显示胆红素血症和苯巴比妥治疗对新生儿血糖代谢的影响。在对照婴儿中，头4天血清胆红素与血糖水平之间存在显著的负相关。肝脏似乎是产生这种关系的一个因素。葡萄糖可能是治疗新生儿高胆红素血症的有用辅助药物。苯巴比妥治疗显著提高了这些婴儿的血糖水平并降低了血清胆红素水平。提示肝功能增强或肝酶诱导可能是其原因。

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引用本文的文献

1

[Some disorders of blood sugar metabolism in newborn infants].

Acta Diabetol Lat. 1972 Jul-Aug;9(4):631-41. doi: 10.1007/BF01564575.

2

The comparative effects of barbituric acid phenobarbital on blood glucose and insulin secretion in mice.

Diabetologia. 1976 Jul;12(3):263-7. doi: 10.1007/BF00422094.

本文引用的文献

1

IMPLICATIONS ON ENZYME INDUCTION FOR DRUG THERAPY.

Am J Med. 1964 Sep;37:327-31. doi: 10.1016/0002-9343(64)90190-1.

2

[THE ISLANDS OF LANGERHANS IN FETAL ERYTHROBLASTOSIS].

Virchows Arch Pathol Anat Physiol Klin Med. 1963 Aug 8;336:544-9.

3

Hypoglycemia due to pancreatic islet cell adenoma.

J Pediatr. 1962 May;60:721-9. doi: 10.1016/s0022-3476(62)80099-7.

4

Bilirubin metabolism in jaundice.

Am J Med. 1958 Jan;24(1):111-21. doi: 10.1016/0002-9343(58)90366-8.

5

Hypoglycemia in the newborn.

Pediatr Clin North Am. 1966 Aug;13(3):905-20.

6

A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency.

Blood. 1966 Oct;28(4):553-62.

7

Hypoglycemia and hyperinsulinemia associated with erythroblastosis fetalis.

Pediatrics. 1969 Feb;43(2):217-25.

8

Hypoglycaemia complicating haemolytic disease of the newborn.

Arch Dis Child. 1969 Apr;44(234):248-51. doi: 10.1136/adc.44.234.248.

9

Barbiturate enhancement of bilirubin conjugation and excretion in young and adult animals.

Pediatr Res. 1968 Sep;2(5):361-70. doi: 10.1203/00006450-196809000-00005.

10

Hypoglycemia in neonatal sepsis.

J Pediatr. 1970 Nov;77(5):812-7. doi: 10.1016/s0022-3476(70)80240-2.

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