昏迷患者脑室脑脊液中的胺类代谢产物
Amine metabolites in ventricular cerebrospinal fluid in coma.
作者信息
Yates C M, Tsementzis S A, Wilson H
出版信息
J Neurol Neurosurg Psychiatry. 1979 Oct;42(10):887-91. doi: 10.1136/jnnp.42.10.887.
The concentrations of homovanillic acid (HVA), 3-methoxy, 4-hydroxyphenylglycol (MHPG), and 5-hydroxyindolylacetic acid (5-HIAA) were measured in samples of ventricular cerebrospinal fluid (CSF) taken from 15 patients who were comatose as a result of an acute head injury, a tumour, or a cerebrovascular accident. The metabolite levels were not related to the ventricular fluid pressure. In the eight patients who recovered and from whom serial samples of CSF were obtained, the metabolite levels did not change, except for two patients in whom HVA increased as coma progressed. The concentration of MHPG, but not of HVA or 5-HIAA, was greater (P less than 0.02) in the five patients who died without regaining consciousness than in the 10 patients who recovered.
在取自15例因急性头部损伤、肿瘤或脑血管意外而昏迷患者的脑室脑脊液（CSF）样本中，测定了高香草酸（HVA）、3-甲氧基-4-羟基苯乙二醇（MHPG）和5-羟吲哚乙酸（5-HIAA）的浓度。代谢物水平与脑室液压力无关。在8例康复且获取了CSF系列样本的患者中，除2例患者HVA随昏迷进展而升高外，代谢物水平未发生变化。在5例未恢复意识而死亡的患者中，MHPG的浓度高于10例康复患者（P<0.02），但HVA和5-HIAA的浓度则不然。
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