关于印度西部一些同族通婚群体中癌症分布情况的一则说明。
A note on the distribution of cancer in some endogamous groups in Western India.
作者信息
Jayant K, Balakrishnan V, Sanghvi L D
出版信息
Br J Cancer. 1971 Dec;25(4):611-9. doi: 10.1038/bjc.1971.77.
Endogamous groups in Western India have been known to have a wide degree of genetic diversity. Analysis of the data available on some of the endogamous groups belonging to two main communities attending the Tata Memorial Hospital, Bombay, viz. Hindus from Maharashtra, and Hindus from Gujarat show that one of the endogamous groups, the Maharashtrian Brahmin has a significantly different pattern of cancer site distribution compared to the other groups studied. Maharashtrian Brahmins have a low relative frequency of cancer of the oral cavity and high relative frequencies of cancer of the oropharynx and cancer of the oesophagus. The tobacco chewing habit pattern seems to have a bearing on the proportion of cancer of the oral cavity observed in the groups studied. However, in the case of cancer of the oropharynx and cancer of the oesophagus, factors besides smoking and chewing habits seem to be playing a role. A further study is indicated to clarify the points raised by the study.
据了解，印度西部的族内通婚群体具有广泛的基因多样性。对孟买塔塔纪念医院收治的两个主要社群中的一些族内通婚群体的现有数据进行分析，即来自马哈拉施特拉邦的印度教徒和来自古吉拉特邦的印度教徒，结果显示，其中一个族内通婚群体，即马哈拉施特拉邦婆罗门，与其他研究群体相比，癌症部位分布模式有显著差异。马哈拉施特拉邦婆罗门口腔癌的相对发病率较低，口咽癌和食道癌的相对发病率较高。在所研究的群体中，嚼烟习惯模式似乎与口腔癌的比例有关。然而，就口咽癌和食道癌而言，除吸烟和嚼烟习惯外的其他因素似乎也在起作用。有必要进行进一步研究以阐明该研究所提出的问题。
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