在苯并芘皮肤涂抹实验中，时间和剂量对肿瘤发生率的影响。
The effect both of time and dose applied on tumour incidence rate in benzopyrene skin painting experiments.
作者信息
Lee P N, O'Neill J A
出版信息
Br J Cancer. 1971 Dec;25(4):759-70. doi: 10.1038/bjc.1971.90.
Abstract
In two separate experiments benzopyrene has been painted regularly on the backs of mice at difference dose levels.It has been shown that the incidence rate of both tumours and infiltrating carcinomas can be taken as proportional to d(2)(t - w)(k) where t is time from first application, w and k are constants independent of dose, and d is the applied dose.
摘要
在两项独立实验中，已以不同剂量水平定期将苯并芘涂抹在小鼠背部。结果表明，肿瘤和浸润性癌的发病率均可视为与d(2)(t - w)(k)成正比，其中t是首次涂抹后的时间，w和k是与剂量无关的常数，d是涂抹剂量。
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