胺碘酮对人体窦房结的影响。
Effects of amiodarone on sinus node in man.
作者信息
Touboul P, Atallah G, Gressard A, Kirkorian G
出版信息
Br Heart J. 1979 Nov;42(5):573-8. doi: 10.1136/hrt.42.5.573.
Abstract
The effects of amiodarone on the sinuatrial node were studied in 24 patients after an intravenous injection of the drug (5 mg/kg). Sinuatrial function was assessed by rapid atrial pacing and premature atrial stimulation. Sinus cycle length did not change significantly, but the corrected sinus node recovery time was prolonged. While there was no significant change in sinuatrial conduction time, prolongation of the non-reset zone in 14 cases, as well as the abolition of the platesu in 2/24 patients, suggested that conduction of the atrial responses to the sinus node might have been depressed.
摘要
在24例患者静脉注射胺碘酮（5mg/kg）后，研究了胺碘酮对窦房结的影响。通过快速心房起搏和房性早搏刺激评估窦房结功能。窦性周期长度无明显变化，但校正的窦房结恢复时间延长。虽然窦房传导时间无明显变化，但14例患者非重置区延长，以及24例中有2例平台消失，提示心房激动向窦房结的传导可能受到抑制。
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