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在为期五年的社区综合心血管疾病防治项目(北卡累利阿项目)中冠状动脉危险因素的变化。

Changes in coronary risk factors during comprehensive five-year community programme to control cardiovascular diseases (North Karelia project).

作者信息

Puska P, Tuomilehto J, Salonen J, Neittaanmäki L, Maki J, Virtamo J, Nissinen A, Koskela K, Takalo T

出版信息

Br Med J. 1979 Nov 10;2(6199):1173-8. doi: 10.1136/bmj.2.6199.1173.

Abstract

A comprehensive community programme to control cardiovascular diseases (CVD) in North Karelia, Finland, was carried out during 1972-7. The central intermediate objective of the programme was to reduce the prevalence of smoking, the serum cholesterol concentration, and raised blood-pressure values among the population of the area. The effect was evaluated by examining independent representative population samples in 1972 and 1977 in both the county of North Karelia and a matched control county. Over 10 000 subjects were studied each time, the participation rate being around 90%. The decrease that occurred in the risk factors, especially in men, was in general greater in North Karelia compared with the control county. When a multiple logistic function was used for the three risk factors an overall mean net reduction of 17% among men and 12% among women was observed in the estimated risk for coronary heart disease in North Karelia. This community programme effectively reduced the levels of the three main risk factors for CVD in the population, and thus mortality and morbidity from CVD should fall. This is assessed in further studies.

摘要

1972年至1977年期间,芬兰北卡累利阿实施了一项控制心血管疾病(CVD)的综合社区计划。该计划的核心中间目标是降低该地区人群中的吸烟率、血清胆固醇浓度和高血压值。通过在1972年和1977年对北卡累利阿县和一个匹配的对照县的独立代表性人群样本进行检查来评估效果。每次研究超过10000名受试者,参与率约为90%。与对照县相比,北卡累利阿的危险因素下降情况,尤其是男性,总体上更大。当对这三个危险因素使用多元逻辑函数时,在北卡累利阿,估计冠心病风险的总体平均净降低在男性中为17%,在女性中为12%。这个社区计划有效地降低了人群中CVD的三个主要危险因素水平,因此CVD的死亡率和发病率应该会下降。这将在进一步的研究中进行评估。

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