重新聚集的脑细胞培养中的突触形成。
Synaptogenesis in reaggregating brain cell culture.
作者信息
Seeds N W, Vatter A E
出版信息
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3219-22. doi: 10.1073/pnas.68.12.3219.
Abstract
Dissociated cells from embryonic mouse brain reassociate in rotation culture to form highly organized aggregates. Electron microscopic observations of aggregates show the presence of synapses that mature and increase in number during culture. Apparent myelination of axons is observed in the aggregates after 5 weeks of culture. Thus, brain cell aggregates perform two highly specialized morphological events that are characteristic of mouse brain differentiation.
摘要
来自胚胎小鼠大脑的解离细胞在旋转培养中重新聚集，形成高度有组织的聚集体。对聚集体的电子显微镜观察显示存在突触，这些突触在培养过程中成熟且数量增加。培养5周后，在聚集体中观察到轴突明显的髓鞘形成。因此，脑细胞聚集体执行了小鼠脑分化所特有的两个高度专业化的形态学过程。
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