正常和糖尿病大鼠骨骼肌核糖体对芜菁黄花叶病毒核糖核酸的结合与翻译
Binding and translation of turnip-yellow-mosaic-virus ribonucleic acid by skeletal-muscle ribosomes from normal and diabetic rats.
作者信息
Rolleston F S, Wool I G, Martin T E
出版信息
Biochem J. 1970 May;117(5):899-905. doi: 10.1042/bj1170899.
Abstract
Ribosomes from skeletal muscle of diabetic rats were less active than normal ribosomes in protein synthesis directed by turnip-yellow-mosaic-virus RNA. The proportion of ribosomes from muscle of diabetic rats capable of binding turnip-yellow-mosaic-virus RNA was greater than normal, but there was no difference in the equilibrium constants for the binding reaction. The turnip-yellow-mosaic-virus RNA was bound preferentially to the small (40S) ribosomal subunit, whereas the decrease due to diabetes in its translation was associated with the large (60S) subunit. Thus the diminished capacity of ribosomes from muscle of diabetic rats to translate turnip-yellow-mosaic-virus RNA was not the result of decreased binding of the template.
摘要
在芜菁黄花叶病毒RNA指导的蛋白质合成过程中，糖尿病大鼠骨骼肌中的核糖体活性低于正常核糖体。糖尿病大鼠肌肉中能够结合芜菁黄花叶病毒RNA的核糖体比例高于正常水平，但结合反应的平衡常数并无差异。芜菁黄花叶病毒RNA优先与小（40S）核糖体亚基结合，而糖尿病导致其翻译减少与大（60S）亚基有关。因此，糖尿病大鼠肌肉核糖体翻译芜菁黄花叶病毒RNA的能力下降并非模板结合减少所致。
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