Botnick L E, Hannon E C, Hellman S
Blood Cells. 1979 Jun 15;5(2):195-210.
The nature of the hemopoietic stem cell compartment has been the subject of much controversy. Data are presented to support the concept of a 'continuum' model of the stem cell compartment. The important characteristics of this model are that within the continuum there are cells with varying proliferative capacities. As cells move through the compartment, their proliferative capacity becomes more limited, their likelihood to be in cycle increases, and their commitment to a specific differentiated pathway increases. Experiments with busulfan, cyclophosphamide, 5-flurouracil, and BCNU demonstrate defects in proliferative potential of the surviving CFU-S population. These defects persist throughout the life of the animal without any evidence of recovery. The clinical implications of late stem cell failure may be important as a consideration in the use of cytotoxic agents.
造血干细胞区室的性质一直是诸多争议的主题。本文提供的数据支持干细胞区室“连续统一体”模型的概念。该模型的重要特征是在连续统一体内存在具有不同增殖能力的细胞。随着细胞在区室中移动，它们的增殖能力变得更加受限，处于细胞周期的可能性增加，并且它们向特定分化途径分化的倾向增加。使用白消安、环磷酰胺、5-氟尿嘧啶和卡氮芥进行的实验表明，存活的脾集落形成单位（CFU-S）群体的增殖潜力存在缺陷。这些缺陷在动物的整个生命过程中持续存在，没有任何恢复的迹象。晚期干细胞衰竭的临床意义在使用细胞毒性药物时可能是一个重要的考虑因素。
