接受皮质类固醇治疗儿童的血浆生长激素浓度
Plasma growth hormone concentration in corticosteroid-treated children.
作者信息
Morris H G, Jorgensen J R, Jenkins S A
出版信息
J Clin Invest. 1968 Mar;47(3):427-35. doi: 10.1172/JCI105739.
Abstract
Endogenous plasma growth hormone concentrations were measured in 23 children who were receiving daily corticosteroid therapy and in 10 control asthmatic children who had not received steroids for at least 8 months. The growth hormone concentrations were similar in the two groups of patients both during the fasting state and after insulin-induced hypoglycemia. 12 children, who were studied while receiving a large dose of prednisone and again 2 wk after steroid withdrawal, also showed no change in growth hormone concentration in relation to corticosteroid therapy. These findings suggest that deficiency of growth hormone is not the major mechanism responsible for the dwarfism of corticosteroid-treated children.
摘要
对23名正在接受每日皮质类固醇治疗的儿童以及10名至少8个月未接受类固醇治疗的对照哮喘儿童测量了内源性血浆生长激素浓度。两组患者在空腹状态和胰岛素诱导的低血糖后生长激素浓度相似。12名在接受大剂量泼尼松治疗时以及停药2周后再次接受研究的儿童，其生长激素浓度也未显示出与皮质类固醇治疗相关的变化。这些发现表明，生长激素缺乏不是皮质类固醇治疗儿童侏儒症的主要机制。
相似文献
1
Plasma growth hormone concentration in corticosteroid-treated children.接受皮质类固醇治疗儿童的血浆生长激素浓度
J Clin Invest. 1968 Mar;47(3):427-35. doi: 10.1172/JCI105739.
2
3
Metabolic effects of human growth hormone in corticosteroid-treated children.生长激素对接受皮质类固醇治疗儿童的代谢影响。
J Clin Invest. 1968 Mar;47(3):436-51. doi: 10.1172/JCI105740.
4
Growth and growth hormone. I. Changes in serum level of growth hormone following hypoglycemia in 134 children with growth retardation.生长与生长激素。I. 134例生长迟缓儿童低血糖后生长激素血清水平的变化
Pediatr Res. 1968 Jan;2(1):43-63. doi: 10.1203/00006450-196801000-00005.
5
Effect of corticosteroid treatment of urinary epinephrine response to induced hypoglycemia in asthmatic children.皮质类固醇治疗对哮喘儿童尿肾上腺素对诱导性低血糖反应的影响。
J Pharmacol Exp Ther. 1973 Jan;184(1):180-8.
6
The plasma cortisol and corticotropin response to hypoglycemia following adrenal steroid and ACTH administration.肾上腺类固醇和促肾上腺皮质激素给药后血浆皮质醇和促肾上腺皮质激素对低血糖的反应。
J Clin Endocrinol Metab. 1975 Jul;41(1):1-6. doi: 10.1210/jcem-41-1-1.
7
[Study on variations in plasma somatotropin in insulin-induced hypoglycemia in infantile dwarfs. with special reference to its diagnostic value in pituitary dwarfs].[婴儿期侏儒症胰岛素诱导低血糖时血浆生长激素变化的研究。特别提及生长激素在垂体性侏儒症中的诊断价值]
Nihon Shonika Gakkai Zasshi. 1968 Apr 1;72(4):426-38.
8
Immunoassay of plasma growth hormone in cats following fasting and administration of insulin, arginine, 2-deoxyglucose and hypothalamic extract.禁食及给予胰岛素、精氨酸、2-脱氧葡萄糖和下丘脑提取物后猫血浆生长激素的免疫测定
Endocrinology. 1971 Feb;88(2):359-66. doi: 10.1210/endo-88-2-359.
9
10
The effect of arginine infusion on plasma growth hormone and insulin in children.精氨酸输注对儿童血浆生长激素和胰岛素的影响。
J Pediatr. 1969 Feb;74(2):187-97. doi: 10.1016/s0022-3476(69)80066-1.
引用本文的文献
1
Growth hormone secretion in growth-retarded asthmatic children.生长发育迟缓的哮喘儿童的生长激素分泌
Br Med J. 1969 Jul 5;3(5661):25-6. doi: 10.1136/bmj.3.5661.25.
2
Metabolic effects of human growth hormone in corticosteroid-treated children.生长激素对接受皮质类固醇治疗儿童的代谢影响。
J Clin Invest. 1968 Mar;47(3):436-51. doi: 10.1172/JCI105740.
3
Cushing's syndrome in childhood.儿童库欣综合征
Can Med Assoc J. 1972 Jan 22;106(2):131-5.
4
The effect of glucocorticoids on thyrotropin secretion.糖皮质激素对促甲状腺激素分泌的影响。
J Clin Invest. 1969 Nov;48(11):2096-103. doi: 10.1172/JCI106176.
5
Growth hormone: metabolic clearance rates, integrated concentrations, and production rates in normal adults and the effect of prednisone.生长激素：正常成年人的代谢清除率、整合浓度和产生率以及泼尼松的影响。
J Clin Invest. 1972 Dec;51(12):3193-9. doi: 10.1172/JCI107146.
6
The effect of corticosteroids on dendritic development in the rat brain.皮质类固醇对大鼠大脑中树突发育的影响。
Yale J Biol Med. 1974 Sep;47(3):155-65.
7
Growth hormone studies in patients with rheumatoid arthritis with or without glucocorticoid therapy.类风湿关节炎患者使用或不使用糖皮质激素治疗时的生长激素研究。
Z Kinderheilkd. 1974;118(1):53-62. doi: 10.1007/BF00506053.
8
Diagnosis and management of hypopituitarism.垂体功能减退症的诊断与管理
J R Coll Physicians Lond. 1972 Oct;7(1):19-33.
9
Night and day growth hormone levels during treatment with corticosteroids and corticotrophin.使用皮质类固醇和促肾上腺皮质激素治疗期间的昼夜生长激素水平。
Arch Dis Child. 1972 Aug;47(254):605-8. doi: 10.1136/adc.47.254.605.
10
Cortisol and growth hormone secretion in relation to linear growth: patients with Still's disease on different therapeutic regimens.与线性生长相关的皮质醇和生长激素分泌：不同治疗方案下的斯蒂尔病患者
Br Med J. 1970 Sep 5;3(5722):547-51. doi: 10.1136/bmj.3.5722.547.
本文引用的文献
1
SECRETION AND METABOLISM OF GROWTH HORMONE IN PREMATURE AND FULL-TERM INFANTS.早产儿和足月儿生长激素的分泌与代谢
J Clin Endocrinol Metab. 1965 Feb;25:209-18. doi: 10.1210/jcem-25-2-209.
2
HUMAN GROWTH HORMONE. CLINICAL MEASUREMENT, RESPONSE TO HYPOGLYCEMIA AND SUPPRESSION BY CORTICOSTEROIDS.人类生长激素。临床测量、对低血糖的反应及皮质类固醇的抑制作用
N Engl J Med. 1964 Dec 31;271:1375-81. doi: 10.1056/NEJM196412312712701.
3
IMMUNOASSAY OF SERUM GROWTH HORMONE IN ACROMEGALIC PATIENTS.肢端肥大症患者血清生长激素的免疫测定
Br Med J. 1964 Nov 14;2(5419):1229-32. doi: 10.1136/bmj.2.5419.1229.
4
EFFECT OF CORTICOSTEROIDS ON SERUM GROWTH HORMONE.皮质类固醇对血清生长激素的影响。
Lancet. 1964 Aug 22;2(7356):376-8. doi: 10.1016/s0140-6736(64)90389-7.
5
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
Biochem J. 1963 Oct;89(1):114-23. doi: 10.1042/bj0890114.
6
APPLICATION OF A FERROCYANIDE-PHOSPHOMOLYBDATE REACTION TO AN AUTOMATED DETERMINATION OF SERUM GLUCOSE.亚铁氰化物 - 磷钼酸盐反应在血清葡萄糖自动测定中的应用。
Clin Chim Acta. 1963 Nov;8:953-9. doi: 10.1016/0009-8981(63)90020-2.
7
IMMUNOASSAY OF HUMAN GROWTH HORMONE IN PLASMA.血浆中人生长激素的免疫测定
Nature. 1963 Aug 24;199:784-7. doi: 10.1038/199784a0.
8
Purification of human growth hormone on "sephadex G-200".在“葡聚糖凝胶G - 200”上纯化人生长激素。
Nature. 1963 Mar 23;197:1206-7. doi: 10.1038/1971206a0.
9
Secretion of human growth hormone: physiologic and experimental modification.人生长激素的分泌：生理及实验性调节
Metabolism. 1963 Jul;12:577-9.
10
Immunoassay of endogenous plasma insulin in man.人体内源性血浆胰岛素的免疫测定。
J Clin Invest. 1960 Jul;39(7):1157-75. doi: 10.1172/JCI104130.
Zotero 插件