Conroy R T, Hughes B D, Milles J N
Br Med J. 1968 Aug 17;3(5615):405-7. doi: 10.1136/bmj.3.5615.405.
Studies of the circadian rhythm in plasma 11-O.H.C.S. levels showed that a subgroup of affective psychotics had higher plasma 11-OHCS values as compared with schizophrenic and other psychotic subgroups, and a somewhat less regular rhythm. One patient with depression who was studied over 48-hour periods showed a reduction in plasma 11-OHCS levels with clinical recovery. An accentuated fall and rise in plasma 11-OHCS values in the night and early morning samples, respectively, was observed in the schizophrenic subgroup.
对血浆11 - 羟基皮质类固醇(11 - O.H.C.S.)水平昼夜节律的研究表明,与精神分裂症患者及其他精神病亚组相比,情感性精神病患者亚组的血浆11 - OHCS值更高,且节律稍欠规律。一名接受了48小时观察的抑郁症患者,随着临床症状的恢复,其血浆11 - OHCS水平有所降低。在精神分裂症亚组中,分别观察到夜间和清晨样本的血浆11 - OHCS值有明显的下降和上升。