网状内皮系统阻断：嘌呤霉素对调理素依赖性恢复的影响。
Reticuloendothelial blockade: effect of puromycin on opsonin-dependent recovery.
作者信息
Pisano J C, Patterson J T, Di Luzio N R
出版信息
Science. 1968 Nov 1;162(3853):565-7. doi: 10.1126/science.162.3853.565.
PMID:5706937
Abstract
Reticuloendothelial blockade induced by the administration of a gelatinized "reticuloendothelial test lipid emulsion" is due to a loss of opsonic activity in the plasma. Recovery from blockade, which is associated with restoration of plasma opsonins, was inhibited by the administration of puromycin. The effect of puromycin appears to be mediated by inhibition of opsonin formation rather than a puromycin-induced macrophage defect in phagocytosis.
摘要
给予凝胶化的“网状内皮系统试验脂质乳剂”所诱导的网状内皮系统阻断是由于血浆中调理活性的丧失。与血浆调理素恢复相关的阻断恢复被嘌呤霉素的给予所抑制。嘌呤霉素的作用似乎是通过抑制调理素的形成介导的，而不是嘌呤霉素诱导的巨噬细胞吞噬缺陷。
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