Yarkoni S, Spitz I M, Ben-David M, Polishuk W Z
Acta Eur Fertil. 1978 Dec;9(4):185-8.
A case of hyperprolactinemic anovulation with amenorrhea and galactorrhea, due to Phenothizine derivative (Majeptil) is presented. Treatment with bromocriptine, 2.5 mg b.i.d., p.o., or L-Dopa, 500 mg, p.o., did not suppress serum prolactin and menstrual cycle was not resumed. Pituitary prolactin response to TRH and Pituitary LH and FSH response to LHRH were found to be normal. It seems that at the dose used, bromocriptine (a dopaminergic agonist) cannot counteract the phenothiazine induced hyperprolactinemia. Hence, it is not effective in induction of ovulation while the patient is under phenothiazine treatment.
本文报告一例因吩噻嗪衍生物（马耶普替）导致高催乳素血症性无排卵、闭经和溢乳的病例。给予溴隐亭2.5毫克，每日两次，口服，或左旋多巴500毫克，口服，均未抑制血清催乳素，月经周期也未恢复。发现垂体催乳素对促甲状腺激素释放激素（TRH）的反应以及垂体促黄体生成素（LH）和促卵泡生成素（FSH）对促黄体生成素释放激素（LHRH）的反应均正常。似乎在所使用的剂量下，溴隐亭（一种多巴胺能激动剂）无法抵消吩噻嗪诱导的高催乳素血症。因此，在患者接受吩噻嗪治疗期间，它对诱导排卵无效。
