P物质对麻醉猫和豚鼠肺阻力及动态肺顺应性的影响。

Effect of substance P on pulmonary resistance and dynamic pulmonary compliance in the anaesthetized cat and guinea-pig.

作者信息

Andersson P, Persson H

出版信息

Acta Pharmacol Toxicol (Copenh). 1977 Nov;41(5):444-8. doi: 10.1111/j.1600-0773.1977.tb02154.x.

DOI:10.1111/j.1600-0773.1977.tb02154.x

Abstract

The effect of substance P, acetylcholine, and histamine on pulmonary resistance (RL) and on pulmonary dynamic compliance (CDYN) was studied in the anaesthetized cat and guinea-pig. In the anaesthetized guinea-pig, substance P (0.1-1.0 microgram/kg) acetylcholine (1.0-10 microgram/kg), and histamine (1.0-10.0 microgram/kg) produced a dose-dependent increase in RL and decrease in CDYN. In the anaesthetized cat, the effect of substance P was weak on both RL and CDYN, whereas histamine (5-50 microgram/kg) produced a dose-dependent increase in CDYN, but the effect on RL was weak. The effect of acetylcholine was qualitatively the same as in the anaesthetized guinea-pig but about 10 times less effective.

摘要

在麻醉猫和豚鼠身上研究了P物质、乙酰胆碱和组胺对肺阻力（RL）和肺动态顺应性（CDYN）的影响。在麻醉豚鼠中，P物质（0.1 - 1.0微克/千克）、乙酰胆碱（1.0 - 10微克/千克）和组胺（1.0 - 10.0微克/千克）使RL呈剂量依赖性增加，CDYN降低。在麻醉猫中，P物质对RL和CDYN的作用较弱，而组胺（5 - 50微克/千克）使CDYN呈剂量依赖性增加，但对RL的作用较弱。乙酰胆碱的作用在性质上与麻醉豚鼠相同，但效力约低10倍。