灵菌红素的生物合成。
Biosynthesis of pulcherriminic acid.
作者信息
MacDonald J C
出版信息
Biochem J. 1965 Aug;96(2):533-8. doi: 10.1042/bj0960533.
Abstract
- Candida pulcherrima was grown on a complex medium to which various compounds had been added to determine their effect on the biosynthesis of pulcherriminic acid. Most of the pulcherriminic acid synthesized by C. pulcherrima PRL2019 was derived from the l-[1-(14)C]leucine added to the medium. 2. The cyclic dipeptide of l-leucine (cyclo-l-leucyl-l-leucyl) was shown, by trapping experiments involving cycloleucyl-leucyl isomers, to be synthesized by strain PRL2019. Cyclo-l-leucyl-l-leucyl was derived from l-leucine and was converted into pulcherriminic acid. Cyclo-l-leucyl-l-leucyl was a precursor of pulcherriminic acid in strain PRL2007 also. 3. The results supported the hypothesis that pulcherriminic acid is derived from l-leucine and that cyclo-l-leucyl-l-leucyl is an intermediate in the biosynthesis.
摘要
- 将各种化合物添加到一种复杂培养基中培养季也蒙毕赤酵母，以确定它们对腐黑素酸生物合成的影响。季也蒙毕赤酵母PRL2019合成的大部分腐黑素酸源自添加到培养基中的L-[1-(14)C]亮氨酸。2. 通过涉及环亮氨酰-亮氨酰异构体的捕获实验表明，L-亮氨酸的环二肽（环-L-亮氨酰-L-亮氨酰）由PRL2019菌株合成。环-L-亮氨酰-L-亮氨酰源自L-亮氨酸，并转化为腐黑素酸。环-L-亮氨酰-L-亮氨酰也是PRL2007菌株中腐黑素酸的前体。3. 这些结果支持了腐黑素酸源自L-亮氨酸且环-L-亮氨酰-L-亮氨酰是生物合成中间体这一假说。
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