桥连咪唑盐在牛超氧化物歧化酶催化作用机制中的参与情况。
The involvement of the bridging imidazolate in the catalytic mechanism of action of bovine superoxide dismutase.
作者信息
McAdam M E, Feilden E M, Lavelle F, Calabrese L, Cocco D, Rotilio G
出版信息
Biochem J. 1977 Oct 1;167(1):271-4. doi: 10.1042/bj1670271.
Abstract
The pulse-radiolysis method has been used to study the catalytic mechanism of O2 leads to dismutation by the Co(II)-substituted bovine erythrocuprein (superoxide dismutase, EC 1.15.1.1). Catalysis is accompanied by spectral changes that may be interpreted in terms of rapid protonation and deprotonation of the Cu-facing nitrogen atom of the imidazolate that bridges the Cu(II) and the Co(II) [or Zn(II)] in the oxidized enzyme. This rapid change permits the possibility that the imidazole is a proton donor in the catalytic reduction of O2 leads to.
摘要
脉冲辐解方法已被用于研究O₂通过钴（II）取代的牛红细胞铜蛋白（超氧化物歧化酶，EC 1.15.1.1）发生歧化反应的催化机制。催化过程伴随着光谱变化，这些变化可以根据氧化态酶中桥连铜（II）和钴（II）[或锌（II）]的咪唑盐中面向铜的氮原子的快速质子化和去质子化来解释。这种快速变化使得咪唑在O₂催化还原过程中作为质子供体成为可能。
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本文引用的文献
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