Fisher S
Immunology. 1966 Aug;11(2):127-36.
India ink or other finely divided agents (trypan blue, saccharated iron oxide, thorotrast, polystyrene latex) were injected intravenously into mice, and sheep erythrocyte stroma injected subsequently by the same route. The splenic uptake of stroma carrying a tag of I was consistently higher in mice treated with the `blockading' agents than in untreated controls, the difference in some experiments being greater than ten-fold. In addition to promoting the splenic uptake of antigen, some of the finely divided agents also enhanced the formation of anti-sheep red cell haemolysin in mice immunized with a single intravenous injection of sheep erythrocyte stroma. India ink injected intravenously caused a significant rise in the splenic weight of mice.
将印度墨汁或其他细分制剂(台盼蓝、含糖氧化铁、钍造影剂、聚苯乙烯乳胶)静脉注射到小鼠体内,随后通过相同途径注射绵羊红细胞基质。在用“阻断”剂处理的小鼠中,携带I标记的基质的脾脏摄取量始终高于未处理的对照组,在一些实验中差异大于十倍。除了促进脾脏对抗原的摄取外,一些细分制剂还增强了用单次静脉注射绵羊红细胞基质免疫的小鼠中抗绵羊红细胞溶血素的形成。静脉注射印度墨汁导致小鼠脾脏重量显著增加。