鼻咽癌白细胞对结核菌素纯蛋白衍生物、Raji细胞提取物及鼻咽癌活检组织提取物的体外免疫反应。
In vitro immune responses to PPD, extracts from Raji cells and nasopharyngeal carcinoma biopsies in NPC leucocytes.
作者信息
Ng W S, Ng M H, Ho H C, Lamelin J P
出版信息
Br J Cancer. 1977 Dec;36(6):713-22. doi: 10.1038/bjc.1977.254.
Peripheral leucocytes from nasopharyngeal carcinoma (NPC) patients and control subjects, which included healthy subjects and patients with other cancers, have been tested against PPD and a panel of extracts from Raji cells and pooled NPC biopsies, using the blast transformation and the macrophage migration inhibition assays. The results of both assays indicated that the in vitro cell-mediated immune (CMI) responses to the Raji-cell extracts and NPC-biopsy extracts were associated with NPC. However, the peripheral leucocytes from NPC patients and control subjects responded similarly to PPD. These results are in general accord with the skin tests reported by Levine et al. (1976) and Ho, Ng and Kwan (1977b). The antigenic specificity of the NPC-associated CMI responses remains, however, to be resolved, as the extracts used in these or in the in vivo CMI studies were heterogeneous mixtures.
已使用淋巴细胞转化试验和巨噬细胞移动抑制试验，对鼻咽癌（NPC）患者以及对照受试者（包括健康受试者和其他癌症患者）的外周血白细胞进行了检测，检测对象为结核菌素纯蛋白衍生物（PPD）以及一组来自Raji细胞和合并的鼻咽癌活检组织的提取物。两种试验的结果均表明，体外细胞介导免疫（CMI）对Raji细胞提取物和鼻咽癌活检组织提取物的反应与鼻咽癌有关。然而，鼻咽癌患者和对照受试者的外周血白细胞对PPD的反应相似。这些结果总体上与Levine等人（1976年）以及Ho、Ng和Kwan（1977b）报道的皮肤试验结果一致。然而，由于这些或体内CMI研究中使用的提取物是异质混合物，与鼻咽癌相关的CMI反应的抗原特异性仍有待确定。
Zotero 插件