Tsudo M, Uchiyama T, Uchino H
J Exp Med. 1984 Aug 1;160(2):612-7. doi: 10.1084/jem.160.2.612.
Two-color fluorescence analysis revealed that Tac antigen, which was previously reported to be restricted to T cells, was expressed on a proportion of normal B cells activated by Staphylococcus aureus Cowan I (SAC). Immunoaffinity-purified interleukin 2 (IL-2) induced the proliferation of SAC-activated B cells, and the proliferation was completely inhibited by anti-Tac antibody, which blocked the membrane binding and action of IL-2. These results suggest that an IL-2 receptor system is directly involved in the B cell immune response.
双色荧光分析显示,先前报道仅限于T细胞的Tac抗原,在一部分被金黄色葡萄球菌Cowan I(SAC)激活的正常B细胞上表达。免疫亲和纯化的白细胞介素2(IL-2)诱导SAC激活的B细胞增殖,并且抗Tac抗体完全抑制了该增殖,抗Tac抗体阻断了IL-2的膜结合和作用。这些结果表明,IL-2受体系统直接参与B细胞免疫反应。