甲状腺激素对体外垂体环磷酸腺苷磷酸二酯酶活性的抑制作用。
Inhibitory effect of thyroid hormones on pituitary cyclic amp phosphodiesterase activity in vitro.
作者信息
Nagasaka A, Hidaka H, Kataoka K, Iwase K, Nakagawa H, Nakai A, Aono T, Ohyama T
出版信息
Neurochem Res. 1984 Jul;9(7):1011-8. doi: 10.1007/BF00964530.
Thyroid hormones effectively inhibited partially purified cyclic AMP phosphodiesterase from the anterior and posterior lobes of bovine pituitary gland competitively with the substrate, but thyronine, diiodotyrosine, monoiodotyrosine, thyrotropin, thyrotropin releasing hormone, dexamethasone, and luteinizing hormone releasing hormone did not inhibit this enzyme activity. Ki values were found to be 1.0 and 2.5 microM for thyroxine, and 8.0 and 13.5 microM for triiodothyronine in the anterior and posterior lobes, respectively.
甲状腺激素可与底物竞争性地有效抑制牛垂体前叶和后叶中部分纯化的环磷酸腺苷磷酸二酯酶，但甲状腺素、二碘酪氨酸、一碘酪氨酸、促甲状腺激素、促甲状腺激素释放激素、地塞米松和促黄体生成素释放激素均不抑制该酶活性。在前叶和后叶中，甲状腺素的Ki值分别为1.0和2.5微摩尔，三碘甲状腺原氨酸的Ki值分别为8.0和13.5微摩尔。
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