[坏疽性脓皮病：氯法齐明治疗]

[Pyoderma gangrenosum: Clofazimine therapy].

作者信息

Beurey J, Weber M, Delrous J L, Chaulieu Y

出版信息

Ann Dermatol Venereol. 1977 Oct;104(10):631-4.

Abstract

Two patients with pyoderma gangrenosum have responded remarkably well to treatment with Clofazimine (Lamprène). The first patient, a 68-year old women suffered from pyoderma gangrenosum of the buttock and left leg and on the incision scar for cancer of the breast. Laboratory findings showed monoclonal dysglobulinemia (alpha 2-kappa 2). A daily dose of 300 mg of Clofazimine resulted in complete healing with ten days. The second patient was a 24-year old women suffering from ulcerative colitis and a rapidly progressing pyoderma gangrenosum of the left leg. The lesions was completely healed after two weeks of Clofazimine therapy. The dosage was 200 mg daily and was increased to 400 mg daily. Our cases showed decreased cellular immunity and their phagocytic activity was variable.

摘要

两名坏疽性脓皮病患者使用氯法齐明（Lamprene）治疗后反应良好。第一名患者是一位68岁女性，患有臀部、左腿以及乳腺癌手术切口瘢痕处的坏疽性脓皮病。实验室检查发现单克隆球蛋白血症（α2-κ2）。每日300毫克氯法齐明的剂量使病情在十天内完全治愈。第二名患者是一位24岁女性，患有溃疡性结肠炎和左腿迅速进展的坏疽性脓皮病。氯法齐明治疗两周后皮损完全愈合。剂量为每日200毫克，后增至每日400毫克。我们的病例显示细胞免疫下降，其吞噬活性各不相同。