峰电位发放神经元之间的分级突触传递。
Graded synaptic transmission between spiking neurons.
作者信息
Graubard K, Raper J A, Hartline D K
出版信息
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3733-5. doi: 10.1073/pnas.77.6.3733.
Abstract
Graded synaptic transmission occurs between spiking neurons of the lobster stomatogastric ganglion. In addition to eliciting spike-evoked inhibitory potentials in postsynaptic cells, these neurons also release functionally significant amounts of transmitter below the threshold for action potentials. The spikeless postsynaptic potentials grade in amplitude with presynaptic voltage and can be maintained for long periods. Graded synaptic transmission can be modulated by synaptic input to the presynaptic neuron.
摘要
分级突触传递发生在龙虾口胃神经节的脉冲神经元之间。除了在突触后细胞中引发与动作电位相关的抑制性电位外，这些神经元还在动作电位阈值以下释放功能上显著量的神经递质。无动作电位的突触后电位的幅度随突触前电压分级变化，并且可以长时间维持。分级突触传递可由突触前神经元的突触输入进行调节。
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本文引用的文献
1
Decremental Conduction over "Giant" Afferent Processes in an Arthropod.
Science. 1972 May 12;176(4035):680-2. doi: 10.1126/science.176.4035.680.
2
A study on the mechanism of impulse transmission across the giant synapse of the squid.
J Physiol. 1958 Aug 29;143(1):114-37. doi: 10.1113/jphysiol.1958.sp006048.
3
Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb.
J Neurophysiol. 1968 Nov;31(6):884-915. doi: 10.1152/jn.1968.31.6.884.
4
Crab muscle receptor which responds without impulses.
Nature. 1968 Jun 22;218(5147):1170-1. doi: 10.1038/2181170a0.
5
Oscillator neurons in crustacean ganglia.
Science. 1971 Mar 19;171(3976):1170-3. doi: 10.1126/science.171.3976.1170.
6
Simpler networks.
Ann N Y Acad Sci. 1972 Aug 25;193:59-72. doi: 10.1111/j.1749-6632.1972.tb27823.x.
7
Electrolocation in fish.
Ann N Y Acad Sci. 1971 Dec 3;188:242-69. doi: 10.1111/j.1749-6632.1971.tb13102.x.
8
Organization of the retina of the mudpuppy, Necturus maculosus. II. Intracellular recording.
J Neurophysiol. 1969 May;32(3):339-55. doi: 10.1152/jn.1969.32.3.339.
9
Decremental conduction of the visual signal in barnacle lateral eye.
J Physiol. 1972 Jan;220(1):145-75. doi: 10.1113/jphysiol.1972.sp009699.
10
Organization of crustacean neuropil. I. Patterns of synaptic connections in lobster stomatogastric ganglion.
J Neurocytol. 1976 Apr;5(2):207-37. doi: 10.1007/BF01181657.
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