脑室内注射氟联苯乙酸和吲哚美辛对发热家兔体温的影响。
Effects of intracerebroventricular floctafenine and indomethacin on body temperature in febrile rabbits.
作者信息
Laburn H, Mitchell D, Stephen J
出版信息
Br J Pharmacol. 1980;71(2):525-8. doi: 10.1111/j.1476-5381.1980.tb10967.x.
Abstract
- We injected the potent prostaglandin synthesis inhibitors, floctafenine and indomethacin, intravenously and intracerebroventricularly in rabbits made febrile by intravenous injection of leucocyte pyrogen. 2. Floctafenine (75 mumol) injected intravenously failed to affect the fever, whereas indomethacin (15 mumol) markedly reduced the fever. 3. When injected into the cerebral ventricles, floctafenine was feebly antipyretic, and then only at a dose ten times the antipyretic dose of indomethacin. 4. Our results support the suggestion that floctafenine has no antipyretic action when administered peripherally. However, its lack of antipyretic effect cannot be explained solely on the grounds that it fails to cross the blood-brain barrier.
摘要
- 我们将强效前列腺素合成抑制剂氟比洛芬酯和吲哚美辛分别通过静脉注射和脑室内注射给予静脉注射白细胞致热原而发热的家兔。2. 静脉注射氟比洛芬酯（75微摩尔）未能影响发热，而吲哚美辛（15微摩尔）则显著降低了发热。3. 当注入脑室时，氟比洛芬酯的解热作用微弱，且仅在剂量为吲哚美辛解热剂量的十倍时才有此作用。4. 我们的结果支持了以下观点：氟比洛芬酯外周给药时无解热作用。然而，其缺乏解热作用不能仅以其未能穿过血脑屏障来解释。
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