溃疡性结肠炎用药对白细胞运动的抑制作用。
Inhibition of leucocyte motility by drugs used in ulcerative colitis.
作者信息
Rhodes J M, Bartholomew T C, Jewell D P
出版信息
Gut. 1981 Aug;22(8):642-7. doi: 10.1136/gut.22.8.642.
Abstract
The effects on leucocyte motility of sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5 amino-salicylic acid have been compared with those of prednisolone and indomethacin. Sulphasalazine, its active metabolite 5 amino-salicylic acid, and prednisolone are all potent inhibitors of leucocyte motility. Sulphapyridine and indomethacin are non-inhibitory. Inhibition of leucocyte motility may explain why sulphasalazine and 5 amino-salicylic acid are effective in ulcerative colitis while sulphapyridine is not. The lack of effect of indomethacin suggests that this action of sulphasalazine does not involve inhibition of prostaglandin synthesis.
摘要
已将柳氮磺胺吡啶（水杨酸偶氮磺胺吡啶）及其代谢产物磺胺吡啶和5-氨基水杨酸对白细胞运动的影响与泼尼松龙和吲哚美辛的影响进行了比较。柳氮磺胺吡啶、其活性代谢产物5-氨基水杨酸和泼尼松龙都是白细胞运动的强效抑制剂。磺胺吡啶和吲哚美辛无抑制作用。白细胞运动的抑制可能解释了为什么柳氮磺胺吡啶和5-氨基水杨酸对溃疡性结肠炎有效而磺胺吡啶无效。吲哚美辛无作用表明柳氮磺胺吡啶的这一作用不涉及前列腺素合成的抑制。
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本文引用的文献
1
Prostaglandins, indomethacin, and ulcerative colitis.前列腺素、吲哚美辛与溃疡性结肠炎
Gastroenterology. 1980 Jan;78(1):193.
2
The chemosuppression of chemotaxis.趋化性的化学抑制
J Exp Med. 1966 Aug 1;124(2):209-26. doi: 10.1084/jem.124.2.209.
3
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
4
Distribution studies of salicylazosulfapyridine and its metabolites.柳氮磺胺吡啶及其代谢产物的分布研究。
Gastroenterology. 1973 Feb;64(2):240-5.
5
The role of intestinal bacteria in the metabolism of salicylazosulfapyridine.肠道细菌在柳氮磺胺吡啶代谢中的作用。
J Pharmacol Exp Ther. 1972 Jun;181(3):555-62.
6
Characterization of the chemotactic activity of casein for neutrophil leucocytes and macrophages.
Experientia. 1972 Sep 15;28(9):1051-2. doi: 10.1007/BF01918666.
7
The effect of complement depletion on neutrophil migration in acute immunologic arthritis.补体耗竭对急性免疫性关节炎中中性粒细胞迁移的影响。
J Immunol. 1972 May;108(5):1414-9.
8
A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphazalazine (Salazopyrin).柳氮磺胺吡啶（水杨酸偶氮磺胺吡啶）对溃疡性结肠炎进行长期维持治疗的对照治疗试验。
Gut. 1973 Dec;14(12):923-6. doi: 10.1136/gut.14.12.923.
9
Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.在结肠炎患者中，以磷酸泼尼松龙21-磷酸酯作为保留灌肠剂给药后血浆泼尼松龙水平。
Br Med J. 1976 Jan 24;1(6003):193-5. doi: 10.1136/bmj.1.6003.193.
10
Anti-inflammatory drugs, prostaglandins and leucocyte migration.抗炎药物、前列腺素与白细胞迁移
Agents Actions. 1976 Sep;6(5):602-6. doi: 10.1007/BF01971577.
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