Galbraith N S, Young S E, Pusey J J, Crombie D L, Sparks J P
Lancet. 1984 Jan 14;1(8368):91-4. doi: 10.1016/s0140-6736(84)90015-1.
A study of routine data on mumps in England and Wales suggests that its epidemiological features are changing from those of an epidemic disease in young adults and older children to a more endemic disease in younger children. Infection now occurs at an earlier age, at which complications are less frequent and symptomless infection may be more common. The incidence of clinical disease may be falling. The high proportion of registered deaths in the middle aged and elderly may be an artifact due to misclassification of causes of death and to misdiagnosis. These changes lessen the need for routine immunisation. Indeed with low acceptance rates of measles vaccination of 50% at age 15 months, mumps/measles routine vaccination at the same age is contraindicated because similarly low acceptance rates might lead to an increase in the number of cases of mumps in older children and young adults, at which ages complications are more frequent.
一项针对英格兰和威尔士腮腺炎常规数据的研究表明,其流行病学特征正在发生变化,从在青少年和大龄儿童中呈流行性疾病,转变为在低龄儿童中更具地方性流行特点。现在感染发生的年龄更小,此时并发症较少见,无症状感染可能更为普遍。临床疾病的发病率可能正在下降。中年和老年人群中登记死亡比例较高,这可能是由于死因误分类和误诊造成的假象。这些变化减少了常规免疫接种的必要性。实际上,鉴于15个月龄儿童麻疹疫苗接种接受率低至50%,同一年龄的腮腺炎/麻疹常规疫苗接种是禁忌的,因为同样低的接受率可能导致大龄儿童和青少年中腮腺炎病例数增加,而在这些年龄段并发症更为常见。