尿芳基硫酸酯酶A变异形式的临床意义。

Clinical significance of a variant form of urinary arylsulfatase A.

作者信息

Kosugi M, Maru A, Mitsuhashi K, Koyanagi T, Ishibashi T, Imai Y

出版信息

Jpn J Exp Med. 1983 Apr;53(2):73-6.

Abstract

A variant form of urinary arylsulfatase A which was not detected in normal voided urine was demonstrated in the urine obtained directly from the renal-pelvis [Ishibashi, T. et al.: Biochim. Biophys. Acta, 616, 218-227 (1980)]. The variant form was not observed in urine collected directly from the ureter during operations for uretero-cutaneostomy or ileal conduit. However, the urine from intubated uretero-cutaneostomy patients collected near the pelvi-ureteric junction showed the presence of the variant form, further suggesting the origin specificity of the variant. This arylsulfatase was not demonstrated in the voided urine from patients with non-urologic malignant disorders such as uterine endometrial, uterine cervical, rectal, pancreas head and gastric carcinomas, in spite of its appearance in high levels in the urine from patients with advanced bladder cancer.

摘要

在直接取自肾盂的尿液中发现了一种正常排尿中未检测到的尿芳基硫酸酯酶A变异形式[石桥，T.等人：《生物化学与生物物理学学报》，616，218 - 227(1980)]。在输尿管皮肤造口术或回肠代膀胱术手术期间直接从输尿管收集的尿液中未观察到这种变异形式。然而，在肾盂输尿管交界处附近收集的输尿管皮肤造口术插管患者的尿液中显示存在这种变异形式，进一步表明了该变异的起源特异性。尽管晚期膀胱癌患者尿液中该酶水平较高，但在患有非泌尿生殖系统恶性疾病（如子宫内膜癌、子宫颈癌、直肠癌、胰头癌和胃癌）患者的排尿中未发现这种芳基硫酸酯酶。