丙烯酸、丙烯酸乙酯和丙烯酸丁酯的皮肤致癌性生物测定

Dermal oncogenicity bioassays of acrylic acid, ethyl acrylate, and butyl acrylate.

作者信息

DePass L R, Fowler E H, Meckley D R, Weil C S

出版信息

J Toxicol Environ Health. 1984;14(2-3):115-20. doi: 10.1080/15287398409530566.

Abstract

Male C3H/HeJ mice (40 per group) were treated with 25-microliter applications of undiluted ethyl acrylate, 1% acrylic acid, or 1% butyl acrylate on the dorsal skin 3 times weekly for their lifetime. A negative control group received acetone (diluent) only, and a positive control group received 0.1% 3-methylcholanthrene (MC). No epidermal tumors were observed in the animals that received any of the three test substances. In the positive control group, 39 animals had skin tumors, including 33 with confirmed squamous-cell carcinomas. Nonneoplastic skin changes such as dermatitis, dermal fibrosis, epidermal necrosis, and hyperkeratosis were observed in several mice that received ethyl acrylate. No statistically significant effects on survival were seen. Therefore, there was no evidence for local carcinogenic activity of acrylic acid, ethyl acrylate, or butyl acrylate under the conditions of these studies.

摘要

雄性C3H/HeJ小鼠（每组40只）在其背部皮肤每周3次涂抹25微升未稀释的丙烯酸乙酯、1%丙烯酸或1%丙烯酸丁酯，持续终生。阴性对照组仅接受丙酮（稀释剂），阳性对照组接受0.1%的3-甲基胆蒽（MC）。接受三种受试物质中任何一种的动物均未观察到表皮肿瘤。在阳性对照组中，39只动物出现皮肤肿瘤，其中33只确诊为鳞状细胞癌。在几只接受丙烯酸乙酯的小鼠中观察到非肿瘤性皮肤变化，如皮炎、真皮纤维化、表皮坏死和角化过度。未观察到对生存有统计学显著影响。因此，在这些研究条件下，没有证据表明丙烯酸、丙烯酸乙酯或丙烯酸丁酯具有局部致癌活性。