Gülker H, Bramann H U, Brisse B, Kuhs H
Med Klin. 1980 Feb 29;75(5):196-8.
Between 1977 and 1979, a combined antiarrhythmic therapy with Quinidine and Verapamil was used to treat 66 patients (aged 16 to 69 years) with chronic atrial arrhythmias of different etiology. In 60% of the 43 cases with atrial fibrillation the combined therapy was effective in reversing atrial fibrillation to regular sinus rhythm. The frequency of successful responses to Quinidine - Verapamil amounted to more than twice compared with earlier therapeutic results with Quinidine only. In 65% of the 23 cases with atrial extrasystoles or atrial tachycardias a significant reduction of the ectopics could be achieved or a regular sinus rhythm could be established. Thus, the combined therapy with Quinidine - Verapamil is very effective in abolishing chronic atrial arrhythmias, especially atrial fibrillation.
1977年至1979年间,采用奎尼丁和维拉帕米联合抗心律失常疗法治疗了66例(年龄在16至69岁之间)病因各异的慢性房性心律失常患者。在43例房颤患者中,60%的患者联合治疗有效,可使房颤转为规则的窦性心律。与仅使用奎尼丁的早期治疗结果相比,奎尼丁 - 维拉帕米联合治疗成功的频率高出两倍多。在23例房性早搏或房性心动过速患者中,65%的患者异位搏动可显著减少或可建立规则的窦性心律。因此,奎尼丁 - 维拉帕米联合治疗在消除慢性房性心律失常,尤其是房颤方面非常有效。