针对小鼠主要组织相容性复合体编码分子的抗原特异性可溶性辅助活性。I. 皮肤移植后因子产生的动力学及H-2区域特异性的基因定位。
Antigen-specific soluble helper activity for murine major histocompatibility complex-encoded molecules. I. Kinetics of factor production after skin transplantation and genetic mapping of the H-2 region specificity.
作者信息
Plate J M, McDaniel C A, Flaherty L, Stimpfling J H, Melvold R W, Martin N Q
出版信息
J Exp Med. 1982 Mar 1;155(3):681-97. doi: 10.1084/jem.155.3.681.
Abstract
Antigen-specific soluble helper molecules are produced during major histocompatibility complex-disparate allograft priming. Genetic mapping studies with appropriate recombinant and mutant lines of mice have defined the antigen specificities of the soluble helper molecules described here as being directed against the H-2Dd molecules. The production of antigen-specific helper molecules is a relatively early event after H-2Dd-region allograft priming. A later phase of factor production near the time of graft rejection also contains nonspecific helper factors and IL-2.
摘要
抗原特异性可溶性辅助分子是在主要组织相容性复合体不相容的同种异体移植致敏过程中产生的。利用合适的重组和突变小鼠品系进行的基因定位研究已确定，此处描述的可溶性辅助分子的抗原特异性是针对H-2Dd分子的。抗原特异性辅助分子的产生是H-2Dd区域同种异体移植致敏后的一个相对早期事件。在移植排斥反应发生时附近的因子产生后期阶段也包含非特异性辅助因子和白细胞介素-2。
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Antigen-specific soluble helper activity for murine major histocompatibility complex-encoded molecules. I. Kinetics of factor production after skin transplantation and genetic mapping of the H-2 region specificity.针对小鼠主要组织相容性复合体编码分子的抗原特异性可溶性辅助活性。I. 皮肤移植后因子产生的动力学及H-2区域特异性的基因定位。
J Exp Med. 1982 Mar 1;155(3):681-97. doi: 10.1084/jem.155.3.681.
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Immunochemical evidence in two haplotypes for at least three D region-encoded molecules, D, L, and R.在两个单倍型中存在至少三种D区域编码分子（D、L和R）的免疫化学证据。
J Immunol. 1981 May;126(5):1713-6.
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In vitro analysis of allogeneic lymphocyte interaction. V. Identification and characterization of two components of allogeneic effect factor, one of which displays H-2-restricted helper activity and the other, T cell-growth factor activity.同种异体淋巴细胞相互作用的体外分析。V. 同种异体效应因子两种成分的鉴定与特性，其中一种表现出H-2限制性辅助活性，另一种表现出T细胞生长因子活性。
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Concanavalin A-inducible, interleukin-2-producing T cell hybridoma.伴刀豆球蛋白A诱导的、产生白细胞介素-2的T细胞杂交瘤
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Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.抗原特异性辅助性T细胞可多克隆地刺激H-2相容和H-2不相容的B细胞母细胞。
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