Fischer F
Fortschr Med. 1982 Jul 8;100(26):1227-9.
Clinical and autoptic investigations of thirty patients suffering from diabetes mellitus and retinopathia proliferans result in these findings: Of the various manifestations of angiopathy only retinopathy (leading symptom), nephropathy, and arterial hypertension are present in all cases, all other forms receeding into the background numerically, though not in potency. 20 cases of nephropathy ended in uremia (cause of death), 10 cases in azotemia. In 14 out of 20 cases of uremia specific glomerulosclerosis (M. Kimmelstiel-Wilson) was stated autoptically, in the remaining 6 cases a different form of nephropathy was found (pyelonephritis, arteriosclerosis renum, chronic glomerulonephritis). In the 10 patients suffering from azotemia, direct causes of death were various general diseases, such as coronary sclerosis, encephalomalacia, pyogenic infections, and acute tuberculosis.
Diabetes mellitus in connection with retinopathia proliferans turns out to be the most serious form of the general diabetic disease.
对30例患有糖尿病和增殖性视网膜病变的患者进行临床和尸检研究,结果如下:在血管病变的各种表现中,仅视网膜病变(主要症状)、肾病和动脉高血压在所有病例中均存在,所有其他形式在数量上退居次要地位,尽管并非在影响力方面。20例肾病患者死于尿毒症(死因),10例死于氮质血症。在20例尿毒症患者中,有14例尸检显示为特异性肾小球硬化(金-威二氏综合征),其余6例发现为不同形式的肾病(肾盂肾炎、肾动脉硬化、慢性肾小球肾炎)。在10例患有氮质血症的患者中,直接死因是各种全身性疾病,如冠状动脉硬化、脑软化、化脓性感染和急性肺结核。
与增殖性视网膜病变相关的糖尿病是糖尿病全身性疾病最严重的形式。