Highton J, Panayi G S, Shepherd P, Wooley P
Ann Rheum Dis. 1982 Dec;41(6):563-8. doi: 10.1136/ard.41.6.563.
The ability of rheumatoid sera to support concanavalin-A transformation of normal lymphocytes was inversely related to serum C1q binding activity. When C1q binding activity of the sera was removed by absorption with staphylococcal protein A, subsequent lymphocyte response increased to the level found in immune-complex negative sera. Gel filtration of a small number of sera suggested that the suppressive material had a molecular weight in the range 1.8-4.9 x 10(5) daltons. Aggregated human gammaglobulin suppressed con-A transformation of normal lymphocytes in a dose-dependent fashion. These results suggest that immune complexes present in rheumatoid sera can suppress lymphocyte responsiveness. The relevance of this observation to be clinical features of rheumatoid arthritis is discussed.
类风湿血清支持正常淋巴细胞伴刀豆球蛋白A转化的能力与血清C1q结合活性呈负相关。当血清的C1q结合活性通过与葡萄球菌蛋白A吸附而去除后,随后的淋巴细胞反应增加到免疫复合物阴性血清中的水平。对少量血清进行凝胶过滤表明,抑制物质的分子量在1.8 - 4.9×10⁵道尔顿范围内。聚合人γ球蛋白以剂量依赖方式抑制正常淋巴细胞的伴刀豆球蛋白A转化。这些结果表明,类风湿血清中存在的免疫复合物可抑制淋巴细胞反应性。本文讨论了这一观察结果与类风湿关节炎临床特征的相关性。