小鼠中开蓬和灭蚁灵的脑部分布区域比较。
Comparison of brain discrete area distributions of chlordecone and mirex in the mouse.
作者信息
Fujimori K, Benet H, Mehendale H M, Ho I K
出版信息
Neurotoxicology. 1982 Oct;3(2):125-29.
Discrete area distributions of chlordecone or mirex in the brain at different times after a single oral administration of the compounds, 50 mg/kg, were investigated. Whole brain and plasma levels of these compounds also were compared. With the same dose of chlordecone or mirex administered to mice, both brain and plasma levels of chlordecone were significantly higher than those of mirex. Chlordecone appeared to distribute to specific discrete areas in the brain--the striatum and medulla/pons areas having higher chlordecone levels and retaining chlordecone longer. Mirex showed less specific distribution in discrete areas. Therefore, it appears that these structurally related analogs exhibited distribution and pharmacokinetic differences.
研究了单次口服50mg/kg的十氯酮或灭蚁灵后，在不同时间大脑中十氯酮或灭蚁灵的离散区域分布情况。还比较了这些化合物在全脑和血浆中的水平。给小鼠施用相同剂量的十氯酮或灭蚁灵后，十氯酮在大脑和血浆中的水平均显著高于灭蚁灵。十氯酮似乎分布于大脑中的特定离散区域——纹状体和延髓/脑桥区域的十氯酮水平较高且保留时间更长。灭蚁灵在离散区域的分布特异性较低。因此，这些结构相关的类似物似乎表现出分布和药代动力学差异。
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