Kaneko Y
Nihon Sanka Fujinka Gakkai Zasshi. 1983 Feb;35(2):117-26.
To elucidate the significance of fibrinolytic enzymes in ovulation, the changes in the levels of plasminogen activator, plasminogen and plasmin activity were examined using prepubertal rats and sows treated with PMS and hCG. The following results were obtained. 1) The superovulation in rats was blocked with antifibrinolytic agents. 2) Plasminogen and plasminogen activator in the supernatant of rat ovarian homogenates increased toward ovulation. But plasmin activity did not show the significant change. 3) When the superovulation of the rats was blocked with indomethacin, plasminogen remained constant, but plasminogen activator was almost affected. 4) In the supernatant of follicle wall homogenates and the follicular fluid of sows, plasminogen decreased, but plasmin activity increased toward ovulation. 5) Plasminogen activator was produced by rat ovarian granulosa cells, but hCG, gonadotropins, prostaglandins and indomethacin did not activate the production of plasminogen activator in the granulosa cells.
为阐明纤溶酶在排卵中的意义，利用经孕马血清促性腺激素（PMS）和人绒毛膜促性腺激素（hCG）处理的青春期前大鼠和母猪，检测了纤溶酶原激活物、纤溶酶原水平及纤溶酶活性的变化。获得了以下结果。1）抗纤溶药物可阻断大鼠的超排卵。2）大鼠卵巢匀浆上清液中的纤溶酶原和纤溶酶原激活物在排卵时增加。但纤溶酶活性未显示出显著变化。3）当用吲哚美辛阻断大鼠的超排卵时，纤溶酶原保持恒定，但纤溶酶原激活物几乎受到影响。4）在母猪卵泡壁匀浆上清液和卵泡液中，纤溶酶原减少，但纤溶酶活性在排卵时增加。5）大鼠卵巢颗粒细胞可产生纤溶酶原激活物，但hCG、促性腺激素、前列腺素和吲哚美辛均未激活颗粒细胞中纤溶酶原激活物的产生。
