Time course of pancreatic protein synthesis following feeding.

It is now well established that hormonal stimulation of the exocrine pancreas by pancreozymin and secretin results in enhanced enzyme secretion and a decrease in total protein synthesis in the early moments following application of the stimulus. The aim of the present study was to establish if the effects previously observed by these secretagogues were physiological. We thus verified the effects of feeding on pancreatic protein synthesis; data show that 45 min after a 15-min meal, protein synthesis is reduced by 18% while increases are observed at 90 and 105 min. These results indicate that the reduction in protein synthesis observed following feeding or hormonal stimulation is a physiological process.