恶性纤维性胸膜肿瘤中间丝的分型
Typing of intermediate filaments in malignant fibrous pleural tumors.
作者信息
Bader H, Altmannsberger M, Osborn M
出版信息
J Cancer Res Clin Oncol. 1984;107(1):42-7. doi: 10.1007/BF00395489.
We report two cases of a malignant fibrous pleural tumor, one of the localized type and one of the diffuse type. In both cases, typing of intermediate filaments by immunofluorescence microscopy showed that the tumor cells were positive for vimentin and negative for (cyto)keratin and desmin. This result supports the concept that malignant fibrous pleural tumors do not arise from the (cyto)keratin-positive pleural mesothelium but from the submesothelial fibrous tissue. Thus, instead of the usual term "malignant fibrous mesothelioma", the term "malignant submesothelial fibrosarcoma" should be preferred.
我们报告了两例恶性纤维性胸膜肿瘤，一例为局限性，另一例为弥漫性。在这两例病例中，通过免疫荧光显微镜对中间丝进行分型，结果显示肿瘤细胞波形蛋白呈阳性，（细胞）角蛋白和结蛋白呈阴性。这一结果支持了恶性纤维性胸膜肿瘤并非起源于（细胞）角蛋白阳性的胸膜间皮，而是起源于间皮下纤维组织的观点。因此，相较于常用的术语“恶性纤维性间皮瘤”，“恶性间皮下纤维肉瘤”这一术语更为合适。
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