Suzuki M, Yabe T, Satake M, Juji T, Hamaguchi H
J Exp Med. 1984 Sep 1;160(3):751-8. doi: 10.1084/jem.160.3.751.
This report demonstrates directly, using two-dimensional gel electrophoresis and alloantisera, the following: (a) The DR4 light chains show a structural polymorphism among the Dw4, DKT2, and DYT cells. (b) Most of the class II light chains consist of the DR light chain. (c) The MT3 molecule is distinct from the DR4 molecule in the Dw4, DKT2, and DYT cells. (d) The MT3 molecule does not show any structural heterogeneity among the Dw4, DKT2, and DYT cells. These results suggest that the dissection of the D specificity among Dw4, DKT2, and DYT is mainly caused by the differences of the DR4 molecules.
(a) DR4轻链在Dw4、DKT2和DYT细胞之间表现出结构多态性。(b) 大多数II类轻链由DR轻链组成。(c) 在Dw4、DKT2和DYT细胞中,MT3分子与DR4分子不同。(d) 在Dw4、DKT2和DYT细胞之间,MT3分子未表现出任何结构异质性。这些结果表明,Dw4、DKT2和DYT之间D特异性的差异主要是由DR4分子的差异引起的。