抑郁酗酒患者下丘脑-垂体-肾上腺轴功能失调。

Dysregulation of hypothalamic-pituitary-adrenal axis function in depressed alcoholic patients.

作者信息

Targum S D, Wheadon D E, Chastek C T, McCabe W J, Advani M T

出版信息

J Affect Disord. 1982 Dec;4(4):347-53. doi: 10.1016/0165-0327(82)90030-1.

PMID:6219148

Abstract

Hypothalamic-pituitary-adrenal (HPA) axis function was examined in 28 hospitalized, withdrawing alcoholic patients. Fourteen patients met DSM-III criteria for Major Depressive Disorder. Elevated 8 a.m. basal cortisols were noted in 7 depressed alcoholic patients (50%) and no non-depressed alcoholics (P less than 0.01). Escape from dexamethasone suppression was noted in 9 depressed alcoholics (64%) and no non-depressed alcoholics (P less than 0.005). The measurement of HPA axis function may be a useful marker for endogenous depression in an alcoholic population.

摘要

对28名住院的正在戒酒的酒精成瘾患者的下丘脑-垂体-肾上腺（HPA）轴功能进行了检查。14名患者符合《精神疾病诊断与统计手册》第三版中重度抑郁症的标准。7名抑郁的酒精成瘾患者（50%）上午8点的基础皮质醇水平升高，而非抑郁的酒精成瘾患者中无此现象（P<0.01）。9名抑郁的酒精成瘾患者（64%）出现地塞米松抑制试验脱抑制现象，非抑郁的酒精成瘾患者中无此现象（P<0.005）。HPA轴功能的测定可能是酒精成瘾人群内源性抑郁的一个有用指标。