头孢克洛和头孢孟多作为壮观霉素的替代药物用于治疗无并发症淋病男性患者。
Cefaclor and cefamandole as alternatives to spectinomycin in the treatment of men with uncomplicated gonorrhoea.
作者信息
Panikabutra K, Ariyarit C, Chitwarakorn A, Saensanoh C
出版信息
Br J Vener Dis. 1983 Oct;59(5):298-301. doi: 10.1136/sti.59.5.298.
Between 25 December 1981 and 11 March 1982, 400 men with uncomplicated gonococcal urethritis were randomly assigned to one of four treatment regimens: spectinomycin 2 g intramuscularly (group A); cefamandole 1 g intramuscularly after probenecid 1 g orally (group B); cefaclor 3 g orally with probenecid 1 g orally (group C); and cefaclor 3 g orally (group D). The cure rates were 91 of 92 (98.9%) in group A, 68 of 96 (70.8%) in group B, 88 of 92 (95.8%) in group C, and 86 of 96 (89.6%) in group D. Cefaclor at a dose of 3 g given orally with 1 g probenecid appears to be an effective alternative to spectinomycin 2 g in the treatment of gonorrhoea in areas where strains of penicillinase producing Neisseria gonorrhoeae (PPNG) are prevalent.
在1981年12月25日至1982年3月11日期间，400例患有单纯性淋菌性尿道炎的男性被随机分配到四种治疗方案之一：肌内注射壮观霉素2g（A组）；口服丙磺舒1g后肌内注射头孢孟多1g（B组）；口服头孢克洛3g加口服丙磺舒1g（C组）；口服头孢克洛3g（D组）。A组92例中有91例（98.9%）治愈，B组96例中有68例（70.8%）治愈，C组92例中有88例（95.8%）治愈，D组96例中有86例（89.6%）治愈。在产青霉素酶淋病奈瑟菌（PPNG）菌株流行的地区，口服3g头孢克洛加1g丙磺舒似乎是治疗淋病的一种有效的替代2g壮观霉素的方法。
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