接种AKR MCF - 247病毒诱导的淋巴瘤所产生病毒的特性分析
Characterization of virus produced by a lymphoma induced by inoculation of AKR MCF-247 virus.
作者信息
Pedersen F S, Buchhagen D L, Chen C Y, Hays E F, Haseltine W A
出版信息
J Virol. 1980 Jul;35(1):211-8. doi: 10.1128/JVI.35.1.211-218.1980.
We report the characterization of the virus produced by a lymphoid cell line derived from a lymphoma of an AKR mouse after injection of the polytropic AKR virus MCF-247. The virus displays polytropic host range properties and is indistinguishable from MCF-247 as judged by analysis of the large RNase T1-resistant oligonucleotides of the RNA genome. Restriction enzyme analysis of cellular DNA revealed the presence of sequences homologous to MCF-247 genomic RNA. The EcoRI cleavage fragments were characteristic of MCF-247 DNA provirus cleavage products.
我们报告了在注射多嗜性AKR病毒MCF - 247后，源自AKR小鼠淋巴瘤的淋巴样细胞系所产生病毒的特性。该病毒表现出多嗜性宿主范围特性，并且通过对RNA基因组中对RNase T1有抗性的大寡核苷酸的分析判断，它与MCF - 247无法区分。对细胞DNA的限制性酶切分析揭示了存在与MCF - 247基因组RNA同源的序列。EcoRI酶切片段是MCF - 247 DNA前病毒酶切产物的特征。
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