麻醉性和惊厥性巴比妥类药物增强γ-氨基丁酸与大鼠脑突触体膜的结合。
Enhancement by anesthetic and convulsant barbiturates of GABA binding to rat brain synaptosomal membranes.
作者信息
Willow M, Johnston G A
出版信息
J Neurosci. 1981 Apr;1(4):364-7. doi: 10.1523/JNEUROSCI.01-04-00364.1981.
Abstract
All of the anesthetic (amylobarbitone, butobarbitone, pentobarbitone, phenobarbitone, and secobarbitone) and convulsant (5-ethyl-5(3'-methylbut-2-enyl) barbituric acid (3M2B) and 5-ethyl-5-(2'-cyclohexylidene-ethyl) barbituric acid (CHEB) barbiturates tested enhanced the binding of GABA to a carefully prepared P2 membrane fraction from rat brain in a dose-dependent manner. These findings are in agreement with the potentiation of the inhibitory effects of GABA in many neuronal systems by both classes of barbiturates.
摘要
所有测试的麻醉性巴比妥类药物（戊巴比妥、异戊巴比妥、仲丁巴比妥、苯巴比妥和司可巴比妥）和惊厥性巴比妥类药物（5-乙基-5-(3'-甲基丁-2-烯基)巴比妥酸(3M2B)和5-乙基-5-(2'-环己叉基乙基)巴比妥酸(CHEB)）均以剂量依赖性方式增强了γ-氨基丁酸（GABA）与精心制备的大鼠脑P2膜组分的结合。这些发现与两类巴比妥类药物在许多神经元系统中增强GABA抑制作用的结果一致。
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