褪黑素在体外可增加大鼠内侧基底下丘脑的环磷酸鸟苷（cGMP）水平，并降低环磷酸腺苷（cAMP）水平。

Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro.

作者信息

Vacas M I, Sarmiento M I, Cardinali D P

出版信息

Brain Res. 1981 Nov 23;225(1):207-11. doi: 10.1016/0006-8993(81)90332-2.

Abstract

Measurement of cyclic nucleotide accumulation in rat medial basal hypothalamus (MBH) incubated in vitro with methoxyindoles indicated that melatonin (10(-8) M or greater) increased significantly cGMP and depressed cAMP levels. Only the effect on MBH cAMP was shared by 5-methoxytryptophol which exhibited a greater activity than melatonin. 6-Fluoromelatonin (10(-7) M) increased cGMP, whereas the effect of 6-hydroxymelatonin was not significant. Both 6-fluoro- and 6-hydroxymelatonin (10(-5) M) depressed MBH cAMP accumulation while only 6-fluoromelatonin affected it at 10(-7) M concentrations. These data suggest that melatonin and 5-methoxytryptophol affect differently cyclic nucleotide content of MBH at physiological concentrations.

摘要

在体外与甲氧基吲哚一起孵育的大鼠内侧基底下丘脑（MBH）中，对环核苷酸积累的测量表明，褪黑素（10^(-8) M或更高）显著增加了cGMP并降低了cAMP水平。只有对MBH cAMP的影响与5-甲氧基色醇相同，5-甲氧基色醇的活性比褪黑素更高。6-氟褪黑素（10^(-7) M）增加了cGMP，而6-羟基褪黑素的影响不显著。6-氟和6-羟基褪黑素（10^(-5) M）均降低了MBH cAMP的积累，而只有6-氟褪黑素在10^(-7) M浓度下对其有影响。这些数据表明，褪黑素和5-甲氧基色醇在生理浓度下对MBH环核苷酸含量的影响不同。