抗单纯疱疹病毒化合物双重组合的不同体外效应。
Different in vitro effects of dual combinations of anti-herpes simplex virus compounds.
作者信息
Schinazi R F, Nahmias A J
出版信息
Am J Med. 1982 Jul 20;73(1A):40-8. doi: 10.1016/0002-9343(82)90061-4.
Five promising antivirals have been tested individually and in pairs on herpes simplex virus (HSV) types 1 (Strain F) and 2 (Strain G) in Vero cells. These are: 9-(2-hydroxyethoxymethyl)guanine (acyclovir, ACV), 9-beta-D-arabinofuranosyladenine (ara-A), 5-trifluorothymidine (TFT), E-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), and phosphonoformate (PFA). Various types of interactions depending on virus type were observed: synergistic [ara-A/TFT; ara-A/BVDU (G); BVDU/PFA (F)]; additive [ACV/ara-A; ACV/TFT; ACV/BVDU; ACV/PFA (G); BVDU/TFT; PFA/ara-A; PFA/TFT]; and sub-additive [ACV/PFA (F); ara-A/BVDU (F) and BVDU/PFA (G)]. Neither antagonism nor interference was noted for any combinations.
已在Vero细胞中对五种有前景的抗病毒药物分别及两两组合进行了针对1型单纯疱疹病毒（F株）和2型单纯疱疹病毒（G株）的测试。这些药物分别是：9-(2-羟乙氧甲基)鸟嘌呤（阿昔洛韦，ACV）、9-β-D-阿拉伯呋喃糖基腺嘌呤（阿糖腺苷，ara-A）、5-三氟胸苷（TFT）、E-5-(2-溴乙烯基)-2'-脱氧尿苷（BVDU）和膦甲酸（PFA）。观察到了取决于病毒类型的各种相互作用类型：协同作用[阿糖腺苷/TFT；阿糖腺苷/BVDU（G株）；BVDU/PFA（F株）]；相加作用[阿昔洛韦/阿糖腺苷；阿昔洛韦/TFT；阿昔洛韦/BVDU；阿昔洛韦/PFA（G株）；BVDU/TFT；PFA/阿糖腺苷；PFA/TFT]；以及亚相加作用[阿昔洛韦/PFA（F株）；阿糖腺苷/BVDU（F株）和BVDU/PFA（G株）]。任何组合均未观察到拮抗作用或干扰作用。
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