Platinum concentrations in human glioblastoma multiforme following the use of cisplatin.

A 24-year-old female with glioblastoma multiforme was not given a nitrosourea because of interstitial lung disease. Cisplatin was administered monthly for five cycles until disease progression. A second debulking procedure was performed and tumor tissue assayed for the presence of platinum. Levels were measurable 7 weeks after the course of treatment.